Flemoklav Solutab is an antimicrobial drug with a wide area of influence. The medicine helps to cope with colds, tonsillitis and pharyngitis. Well tolerated by patients. It is considered one of the safest antibiotics. "Flemoklav Solyutab" during pregnancy is also allowed to apply. Studies have shown that this medication does not harm the fetus and does not adversely affect the condition of a pregnant woman.
Flemoklav Solyutab: composition of the drug
This medicine is made only in tablets. Pills are oblong white with a slight yellowish tinge. They are made in various concentrations. 125 mg of amoxicillin and 31.25 mg of clavulanic acid (clavulanic acid) may be present in Flemoklav Solutab. Tablets are produced with a content of 250, 500 mg of amoxicillin and 62.5, 125 mg of clavulanate, respectively. The largest concentration of active ingredients is in the Flemoklav Solutab drug 875/125 (during pregnancy this form of release is rarely prescribed by a doctor), where 875 mg of amoxicillin and 125 mg of clavulanic acid.
The minor components in the composition of the tablets are microcrystalline cellulose, vanillin, magnesium stearate, crospovidone, saccharin, a perfume with an apricot aroma. Tablets are packed in aluminum blisters of 4 or 7 pieces. The package can contain from 14 to 20 tablets.
The drug is dispensed from pharmacies without a doctor's prescription. The shelf life of the drug is three years from the date of its manufacture. The medication should be in a dry and cool place, reliably protected from children, at a temperature of up to + 25 ° C.
Pharmacological action of the drug
"Flemoklav Solutab" during pregnancy is prescribed quite often. This is the most gentle penicillin antibiotic. Refers to beta-lactamase inhibitors. The drug is combined and contains two active substances. These are amoxicillin and clavulanate. Many patients are interested in the question: "Amoxicillin - is it an antibiotic or not?" The answer is unequivocal. Amoxicillin is an antibiotic and is often used to treat respiratory, viral, and infectious diseases.
This drug affects the body bactericidal. It inhibits the walls of bacteria. It shows its activity both in relation to gram-negative and in relation to gram-positive microorganisms. This includes strains that beta-lactamase produces. The antibiotic includes clavulanic acid. Why is this component present in antibiotics? First of all, clavulanic acid inhibits types II, III, IV and V beta-lactamases, but does not show its activity against type I beta-lactamases. Successfully manifests its effect in combination with penicillins. This combination prevents the degradation of amoxicillin under the influence of beta-lactamases. Significantly expands the scope of the drug.
The bioavailability of amoxicillin is 94%. The absorption of the active substance is not affected by food intake. The highest plasma concentration of amoxicillin is observed after a couple of hours. After a single use of a tablet with a dosage of 500/125 mg, after eight hours, the average concentration of amoxicillin is 0.3 mg / L. This component interacts with proteins by 17–20%. It has the ability to penetrate the placenta. A small amount is found in breast milk.
Amoxicillin is 10% metabolized in the liver. About 50% of the drug is excreted by the kidneys. The rest of the drug comes out with bile. The half-life in patients who do not have problems with the work of the kidneys and liver is six hours. If the patient suffers from anuria, then the half-life increases to 10-12 hours. The drug may be excreted during hemodialysis.
The bioavailability of clavulanate is 60%. The absorption process is not affected by food intake. The highest concentration of this active substance in the blood is observed two hours after the use of tablets. If you take the Flemoklav Solutab tablet 125/500 mg (clavulanate / amoxicillin), then in eight hours the highest concentration of clavulanic acid will be 0.08 mg / l. Clavulanate binds to blood proteins by 22%. Penetrates freely through the placental barrier. Data on the penetration of this substance into breast milk are not available.
Clavulanic acid is metabolized by 50–70% in the liver organ. About 40% of this substance is excreted by the kidneys. The elimination half-life is 60 minutes.
Indications for use of tablets
"Flemoklav Solutab" during pregnancy can be prescribed to patients in case of emergency. Indications for the use of this medication are diseases of an infectious and inflammatory nature, pathology of the upper respiratory tract, diseases of the ENT organs, among them sinusitis, pharyngitis, otitis media, tonsillitis. The drug is prescribed for pathologies of the lower respiratory tract, when bronchitis or community-acquired pneumonia are diagnosed. Moreover, the drug is taken both in acute and in the chronic stage of the development of the disease. The medication is prescribed for infectious diseases of the skin and soft tissues, diseases of the genitourinary system and renal organ.
With extreme caution, tablets are prescribed for renal and liver failure. With pathologies of the gastrointestinal apparatus, including when a history of colitis.
Application
"Flemoklav Solutab" during pregnancy is prescribed when antibiotic therapy is vital for a woman, and more sparing drugs do not help. In other words, as a last resort. As a result of numerous studies, it was found that the medication does not have a pathogenic effect on the development of the fetus and on the condition of the newborn child. The use of these tablets in the II and III trimester is considered safe. "Flemoklav Solutab" during pregnancy in the 1st trimester is prescribed with extreme caution.
This drug is allowed to be used during lactation. Despite the fact that amoxicillin passes into breast milk, it does not have a negative effect on the baby. The combination of substances such as amoxicillin and clavulanic acid does not adversely affect the baby.
Contraindications
Flemoclav Solutab is not prescribed for hypersensitivity to the components that appear in the composition of the drug. Do not prescribe medication with hypersensitivity to beta-lactam antibiotics, to cephalosporin preparations and with hypersensitivity to penicillins.
Contraindication to the use of the drug is a dysfunction of the liver organ, jaundice, which at the time of taking Flemoklav Solyutaba are in history. In patients diagnosed with lymphocytic leukemia and infectious mononucleosis, the likelihood of exanthema increases. Because of this, the combination of amoxicillin with clavulanate should not be prescribed for these diseases.
Flemoklav Solyutab: instructions for use during pregnancy
In order to exclude dyspeptic symptoms during treatment with “Flemoklav Solutab”, tablets should be taken at the very beginning of a meal. The pill should be swallowed whole, washed down with water. If the tablet is hard to swallow, then you can dissolve it in 100 g of water, and drink the resulting solution.
The severity of the disease affects the duration of treatment. The course of therapy should not exceed 14 days.
Pregnant women, adults and children weighing 40 kg or more are prescribed 500 mg / 125 mg three times a day. If the disease proceeds in a severe form, becomes chronic or is accompanied by complications, then the dosage is doubled.
The dosage of Flemoklava Solutab during pregnancy should not exceed the recommended above. The use of the drug in the II and III trimesters is made after assessing the benefit of the drug for the mother and the possible risk for the child. Pregnant women should avoid taking tablets with a dosage of active substances of 875 mg / 125 mg. Pills with a concentration of active ingredients of 125 mg / 31.25 mg, 250 mg / 62.5 mg, 500 mg / 125 mg can be used in all trimesters of pregnancy. In the first trimester, these tablets are taken with extreme caution.
Children from two to twelve years old, whose mass varies in the region of 13–37 kg, are prescribed a daily dosage of amoxicillin in the amount of 20–30 mg and clavulanate in a dose of 5–7.5 mg. This amount of drug is calculated per 1 kg of the child’s body weight. As a rule, at the age of 2-7 years, babies are prescribed one tablet 125 / 31.25 mg three times a day.
In the age category of seven to twelve years, the drug is prescribed one pill 250 / 62.5 mg three times a day. If severe infectious diseases occur, then the dosage is doubled. The maximum possible dose for a child is 60 mg of amoxicillin and 15 mg of clavulanate, calculated per 1 kg of weight.
For children from three months to two years of age with a weight of 5-12 kg, the drug is prescribed 20-30 mg of amoxicillin and 5-7.5 mg of clavulanate per kilogram of baby's weight. Usually this is a dose of 125 / 31.25, which should be taken twice a day.
In patients suffering from renal failure, the elimination of this drug is slowed down, so their treatment is carried out according to the following scheme:
If GFR (glomerular filtration rate) is 10-30 ml / min., Then the dosage of amoxicillin for adults is 500 mg twice a day, for children - 15 mg / kg, taken twice a day.
With GFR more than 10 ml / min. the dose of amoxicillin for adults is 500 mg per day, for children - 15 mg / kg per day.
During hemodialysis, adults are prescribed 500 mg of amoxicillin per day, 500 mg during dialysis and 500 mg after it.
Patients with impaired liver function, the drug is prescribed with extreme caution. When taking Flemoklava Solutab, these patients should be monitored by a doctor who carefully monitors the liver.
Side effects
Indications for use "Flemoklav Solyutab" during pregnancy are exactly the same as in other people. When taking this drug in pregnant women, adults and children, sometimes negative reactions of the body occur.
This is primarily an allergy, which manifests itself in the form of urticaria, rashes of an erythematous nature, dermatitis, Stevens-Johnson syndrome. In isolated cases, measles exanthema may occur. These body reactions depend on the condition of the patient, the severity of the disease and the prescribed dosage.
When taking Flemoklav Solutab tablets, negative reactions of the digestive system are possible. They appear in the form of nausea, gag reflex, diseases of the liver organ, increased activity of “liver” transaminases. Rarely enough, when taking this drug, cholestatic jaundice, colitis and hepatitis occur.
When taking the drug, there is an increase in alkaline phosphatase, transaminase (ACT and ALT), bilirubin in men and the elderly from 65 years.
Among other adverse reactions of the body, candidiasis, an increase in prothrombin time and progression were observed.
An overdose of this medication can cause vomiting, diarrhea, nausea, and other gastrointestinal upsets. Possible violation of electrolyte and water metabolism.
If overdose symptoms occur, activated charcoal is prescribed. If convulsions occur, prescribe diazepam. Other adverse reactions are treated symptomatically. If renal failure occurs, hemodialysis is performed.
General directions
Many patients, seeing the composition of Flemoklav Solyutab, ask the question: “Amoxicillin is an antibiotic or not?” Yes, this drug, like the active component amoxicillin, is an antibiotic belonging to the penicillin series.
In patients with hypersensitivity to the components of this drug, an anaphylactic reaction may occur. Therapy in this case should be urgently canceled and the patient should be prescribed a more suitable treatment. To eliminate anaphylactic shock, an injection of adrenaline and corticosteroids is urgently needed.
There is a possibility of hypersensitivity and cross-resistance to cephalosporins and other penicillins. As with other antibiotics, when taking Flemoklava Solutab, infections of a bacterial and fungal nature may occur, including candidiasis. When superinfection occurs, the drug is canceled, and treatment is reviewed.
In rare cases, an increase in prothrombin time is observed. Flemoklav Solutab is prescribed with caution to patients undergoing anticoagulation treatment.
Non-enzymatic methods for determining the amount of sugar in the urine, as well as conducting a test for urobilinogen, can give a false positive result.
Flemoklav Solutab contains clavulanic acid. It shows little activity against enterococci and Pseudomonas aeruginosa. Moderately affects the hemophilic bacillus and enterobacteria. To a greater extent, the drug is active against bacteroids, streptococci, moraxella and staphylococci. Beta-lactam compound acts on legionella and chlamydia. This is why clavulanic acid is present in antibiotics. It expands their scope and enhances effectiveness.
Cost
The drug "Flemoklav Solyutab" can be purchased without problems at any pharmacy. He is released without a doctor’s prescription. It costs around 400 rubles for 20 tablets. The price depending on the margin at the outlet may vary slightly.
Reviews of pregnant women
Reviews about "Flemoklava Solutab" during pregnancy are mostly positive. Women note that during treatment they did not experience any adverse reactions. The drug was well tolerated. He helped many ladies in a position to cure purulent tonsillitis, lingering cough, cystitis. Often prescribed for influenza, acute respiratory viral infections and sinusitis. In all of the above cases, he showed himself only on the positive side and did not cause negative phenomena.
The only negative women consider the size of the tablets. According to them, with angina they are difficult to drink. For this reason, many ladies diluted the drug in water and took the medicine in liquid form.
In all cases when the drug was prescribed for pregnant women, it coped with the task perfectly and did not cause complaints from the patients.